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Editorial Volume 6 Issue 2
Is idiopathic pulmonary fibrosis - is environmental or genetic disease - an old wine in a new bottle of treatment
Pranab kumar Bhattacharya, Sumana Mukherjee, Upasana Bhattacharya, Rupak Bhattacharya, Ritwick Bhattacharya, Rupsa Bhattacharya, Dalia Mukherjee, Ayishee Mukherjee, Debasis Mukherjee, Hindole Banerjee, Subhadeep Panda, Arnab Roy
Received: January 01, 1971 | Published: March 8, 2018
Citation: Bhattacharya PK, Mukherjee S, Bhattacharya U,et al. Is idiopathic pulmonary fibrosis - is environmental or genetic disease - an old wine in a new bottle of treatment. Int Clin Pathol J. 2018;6(2):76–78. DOI: 10.15406/icpjl.2018.06.00160
Abstract
Idiopathic Pulmonary Fibrosis is a chronic progressive(IPF) and fibrotic lung disease, where healthy lung is replaced by altered extra cellular matrix, alveolar architecture is gradually destroyed, with gradual increase of fibrosis due to deficient fibroblasts activation and proliferation and all these leads to decreased lung complaints and disrupted gas exchange, ultimately respiratory failure and death. It was previously known as most common type of Idiopathic Interstitial Pneumonia and treatment of choice was (before 2000) prednisolone or prednisolone with azathioprine or acetylcysteine and or warfarin with poor prognosis and median survival time was then for 2 to 4 years after diagnosis. But in less than 10 years time, the landscape of idiopathic pulmonary fibrosis it’s patho physiology, diagnostic modality, pathology and treatment had been transformed. Many people no longer consider IPF to be idiopathic rather interactions between casual factors including genetic polymorphism, aging, environmental exposures, which culminate in a melaptine repair process.
Keywords: Idiopathic pulmonary fibrosis, muc5b gene defect, shortening of aec2 stem cell telomere length, chronic inflammatory, prednisolone, biomechanics, progression, hyper plastic, mechanoreduction, abnormal gas exchange
©2018 Bhattacharya, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.