Case Report: Hypereosinophilic Syndrome Response to Infliximab in a Patient with Ulcerative Colitis

doi:10.15406/ghoa.2016.05.00158

eISSN: 2373-6372

Gastroenterology & Hepatology: Open Access

Case Report Volume 5 Issue 5

Case Report: Hypereosinophilic Syndrome Response to Infliximab in a Patient with Ulcerative Colitis

Solano Marina,¹ Lacarta Pedro,¹ Ferrández Ángel,^1,2

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Gomollón Fernando,^1,2 Lanas Ángel^1,2

¹Department of Digestive Diseases, Hospital Clínico Universitario Lozano Blesa, Spain
²CIBERehd, Spain

Correspondence: Ferrández Ángel, Department of Digestive Diseases, Hospital Clínico Universitario Lozano Blesa, Zaragoza. San Juan Bosco nº 15, 50009 Zaragoza, Spain , Tel 976765700

Received: September 11, 2016 | Published: November 28, 2016

Citation: Marina S, Pedro L, Ángel F, Fernando G, Ángel L (2016) Case Report: Hypereosinophilic Syndrome Response to Infliximab in a Patient with Ulcerative Colitis. Gastroenterol Hepatol Open Access 5(5): 00158. DOI: 10.15406/ghoa.2016.05.00158

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Abstract

Introduction: We present a case of a caucasian 83-year-old female with a previous diagnosis of ulcerative colitis (UC) admitted to our institution with a mild UC flare and a hypereosinophilic overlap syndrome refractory to corticosteroids but that responded to intravenous infliximab.

Conclusion: Hypereosinophilic Syndrome (HES) is a very rare disorder that usually appears in people between 20 to 50 years old although it can also occur in elderly people and children. It affects equally to both sexes and several mechanisms have been proposed related to the excess in the synthesis of eosinophils. The clinical course may be silent or present different manifestations depending on the affected tissue. The diagnostic workup should include blood tests, imaging tests and tissue biopsies. A bone marrow aspiration and biopsy are necessary if all the previous studies are normal. Early diagnosis and treatment of HES have a significant impact on survival. Treatment of asymptomatic patients is based on close monitoring to prevent complications. In symptomatic cases, empiric corticosteroids or other immunosuppressive agents should be used. Hematopoietic cell transplantation is the last therapeutic alternative.

Keywords: Hypereosinophilic Syndrome (HES), Ulcerative Colitis, Infliximab, hypereosinophilia

Introduction

There are many conditions associated with plasma and tissue eosinophilia (Table 1).The degree of eosinophilia can be mild (500-1500 Eos/mL), moderate (1500-5000 Eos/mL) or severe (>5000 Eos/mL). Hypereosinophilic Syndrome (HES) is defined as either hypereosinophilia over 1500 eosinophils/mL in at least 2 determinations or as tissue damage secondary to eosinophilic infiltration.^1,2 The present case report is a patient with a previous diagnosis of ulcerative colitis (UC) admitted to our institution with a suspected mild UC flare and a hypereosinophilic overlap syndrome refractory to corticosteroids but who responded to infliximab.

Allergies

Infections

Lynphoproliferative disorders

Neoplasms

Organ specific diseases

Immunological

Endocrine

Table 1 Pathologies associated with eosinophilia

Case report

A caucasian 83-year-old female with no drug allergies and with a previous history of extensive UC diagnosed 2 years before being admitted to our hospital on September 8th 2013 due to bloody diarrhea, with 18-20 passes per day during the last month. She also complained of abdominal pain, hyporexia and weight loss. She was hemodynamically stable, with mild signs of dehydration. Physical examination showed diffuse abdominal pain but no signs of peritoneal irritation and peristalsis was preserved. She presented edema with fovea in both lower limbs extended to both knees. Digital rectal examination did not reveal masses.

Laboratory tests showed inflammatory activity with erythrocyte sedimentation rate (ESR) 50 mm, C reactive protein (CRP) 2.52 mg/dL, 28500 leukocytes/mm3 (neutrophils 17000/mm3, eosinophils 8900/mm3), 445000/mm3 platelets, hemoglobin 12.3 g/dL, blood iron 19 mg/dL, albumin 1.8 g/d. According to Truelove criteria, the patient has a severe flare up (21 points). She had an abdominal RX done which showed nothing relevant and she was started on intravenous corticosteroids and antibiotics (ciprofloxacin plus metronidazole), oral nutritional and iron supplementation. A colonoscopy was performed and revealed a severe ulcerative colitis. No histological or immunohistochemical signs of super infection by cytomegalovirus (CMV) were observed. Stool cultures and parasites in stool were both negative.

Clinical evolution was good and the patient was discharged from hospital with oral medication and ambulatory monitoring. Two weeks later, on September 26th, the patient was again admitted with a mild UC flare. Laboratory tests showed thrombocytopenia (77000 mil/mm3) and an increased leucocyte (36,300 per mm3) and eosinophil (19,700 per mm3) count. Eosinophilia was present 5 months before the flare (since May 2013), before corticoid therapy was used, with a steady and significant increase to 31.400/mm3 (Figure 1). Bone marrow aspiration, gallium scintigraphy and abdominal CT scan were performed to rule out a myeloproliferative syndrome. They were normal and the patient was diagnosed an overlap Hypereosinophilic Syndrome. Clinical evolution was torpid and the patient developed nosocomial pneumonia and urinary tract infection by E. Coli and Proteus miriabilis receiving broad-spectrum antibiotic. Once myeloproliferative syndrome was excluded the patient was treated with intravenous Infliximab (5 mg/kg) achieving clinical and biochemical remission after the second infusion. After one year of infliximab treatment the patient remains in complete remission(Figure 1).

Figure 1 Infliximab infussion

Discussion

Hypereosinophilic Syndrome (HES) is a rare disorder that usually appears in people between 20 to 50 years old but it can also occur in elderly people and children. Both sexes are affected in the same proportion. Several mechanisms have been related to the overproduction of eosinophils:

Clonal eosinophil proliferation secondary to a primary genetic defect that alters hematopoiesis stem cell and/or defects in the signal transducing receptors mediators of lymphopoiesis
Overproduction of cytokines such as IL-5.
Regulatory defects in the suppressor system of eosinophilopoiesis. The World Health Organization established a classification of different molecular subtypes for eosinophilia:

Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGR1,
Unexplained chronic eosinophilic leukemia,
Lymphocytic eosinophilia and
HES, this, being an exclusion diagnosis.^1,3,4.

The clinical course may be silent or presenting dermatological (37%), pulmonary (25%), gastrointestinal (14%) or cardiac (5%) manifestations. Liver involvement may occur as a chronic active hepatitis, hepatic focal lesions, eosinophilic cholangitis or Budd Chiari syndrome. The diagnostic workup should include blood tests including liver enzymes, creatine kinase, troponins and renal function, electrocardiogram, echocardiogram, chest radiography, chest and abdominal CT, and tissue biopsies. Several biomarkers are currently under study and could be useful as predictors of different subtypes of HES. Serum tryptase, vitamin B12 and serum IgE have to be analyzed. A bone marrow aspiration and biopsy with immunohistochemical and molecular techniques (1, 5) are necessary if all the previous studies are normal.

Treatment of asymptomatic patients is based on close monitoring to prevent complications. In symptomatic cases, empiric corticosteroids should be started (which are the first option in lymphoid variants). Other drugs such as Imatinib (for PDGFRA or PDGFRB variants), hydroxyurea or leukapheresis are used in refractory cases to steroids. Treatment with alpha interferon, mepolizumab (anti-IL5), alemtuzumab (anti-CD52) and other chemotherapeutic agents such as cladribine, chlorambucil, vincristine, methotrexate, cyclosporine and etoposide have been evaluated in specific cases. Hematopoietic cell transplantation should be considered as the last therapeutic alternative when everything else has failed.^1-10 Anti-TNF administration has been reported to induce severe eosinophilic gastroenteritis in a patient with Crohn's Disease.¹¹ However, we believe, according to our experience that infliximab administration is safe in such patients, and that eosinophilic gastroentritis is more probably to be secondary to the disease instead of the medication.

Conclusion

In conclusion, the overlap between HES and other conditions, such us in our patient UC, may response to the treatment of the underlying disease.¹² Infliximab can be a good therapeutic alternative, when conventional medical treatment fails. Early diagnosis and treatment of HES have a significant impact on survival that increases from 12% at 3 years in cases of delayed diagnosis to 80% at 5 years in the case of early diagnosis.¹

Consent Statement

Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

Authors Contribution Section

MS and PL were in charged of the patient and drafted the manuscript. FG participated in the design of the case report. AF coordinated and helped to draft the manuscript. AL supervised the manuscript once it was finished. All authors read and approved the final manuscript.