Case of inherited epidermal growth factor receptor (EGFR) in non-small cell lung carcinoma (NSCLC) in a 37-year-old male
Lung adenocarcinoma is a lung malignancy most known for its prevalence among nonsmokers compared to the other non-small cell and small cell lung cancers. There is a genetic component involving a gene mutation of the epidermal growth factor receptor which depending on the type of mutation can be responsive to tyrosine kinase inhibitor therapy. However, there are rare mutations that cause resistance to first line treatment and require further genetic analysis on the type of gene mutation. We present a young 37-year-old non-smoking male patient who developed an inherited lung adenocarcinoma. His genetic screening indicated he had a germline T790M mutation in his EGFR which is particularly uncommon. He was fortunately responsive to third-line treatment therapy. With this particular diagnosis, routine screening has no benefit, but it is important for family members to be screened as this particular malignancy was inherited.