The potential of glycoproteomics for analyzing proteins associated with cardiovascular diseases are discussed.
Keywords: glycoproteomics, extracellular matrix, myocardial infarction
Protein glycosylation, an enzyme-directed site-specific process, is one of the most common co-translational and post-translational modifications.1 Glycoproteins modulate multiple biological processes, including cell adhesion and migration, signal transduction, and cell-cell communication.2,3 Despite its widespread importance, glycoproteomics is not commonly used for studying cardiovascular disease compared to other diseases, such as cancers and diabetes. Glycoproteomics has the potential to be a powerful tool for analyzing proteins associated with cardiovascular diseases, as discussed below.
Glycosylation is a highly abundant modification crucial for the regulation of protein function, including proteolytic cleavage by enzymes and intra-protein interaction. Glycoproteomics is a logical approach to target specific subproteome with improved sensitivity for low abundant proteins. Therefore, glycoproteomics presents a new direction in methods that allow proteins associated with cardiovascular disease to be assessed for potential use as biomarkers or drug targets.
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The author declares no conflict of interest.
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