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Advances in
eISSN: 2572-8490

Tissue Engineering & Regenerative Medicine: Open Access

Mini Review Volume 4 Issue 1

The use of phototherapy for healing treatments: study of new techniques for tissue neoformation

Renato Cesar da Silva Agnello, Suellia Rodrigues Fleury Rosa, Malrio Fabríclcio Fleury Rosa, Bruno da Costa Motta

Biomedical Engineering Laboratory, University of Brasilia, Brazil

Correspondence: Renato CS Agnello, Graduation student of Electronic Engineering, Biomedical Engineering Laboratory, University of Brasilia, Quadra 107, Lote 18, Casa 11, Condomíclnio Village Saint Clair, Brasícllia, Brazil, Tel +5561999405107

Received: September 18, 2017 | Published: January 8, 2018

Citation: Agnello RCS, Rosa SRF, Rosa MF, et al. The use of phototherapy for healing treatments: study of new techniques for tissue neoformation. Adv Tissue Eng Regen Med Open Access. 2018;4(1):408–409. DOI: 10.15406/atroa.2018.04.00068

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According to the Brazilian Association of Endocrinology and Metabolism, diabetes, or Diabetes Mellitus, is a chronic, autoimmune disease, characterized by the deficiency of insulin production by the body. The problem involves the metabolism of glucose in the blood and can be presented in several ways. The best known types of diabetes are 1 and 2. Beta- cell failure in the pancreas characterizes the first, which affects children and adolescents more often. Type 2 diabetes, whose genetic load is much higher, occurs due to resistance to insulin action, with obesity as one of the main triggering factors. The other forms of diabetes can be manifested by anatomical lesions in the pancreas, due to several toxic aggressions, by infections, chemical compounds, among others. A very common consequence of diabetes it’s a formation of skin wounds due to metallic disorders, these wounds can be very aggressive and diminish the quality of life of the patients. Anequipment based on phototherapy associated with a latex blade was developed as an alternative treatment for skin wounds, the equipment works directly on the neoformation of the wounded tissue, accelerating the scarring process at a low cost.

Keywords: tissue neo formation, new technique, low cost, LED


LED, light emitting diode


Diabetes is a disease that encompasses various metabolic disorders in which the blood glucose index gets high. This disease can cause wounds in the feet caused by a set of alterations in the lower limbs, being injuries in the nerves, alterations in the arteries, the reduction of immunity and, sometimes, alterations in the bony anatomy of the feet. This consequence is called diabetic foot.1

A skin lesion triggers a series of biochemical events aimed at restoring vascular and cellular integrity. During the healing process, the tissue is vulnerable to several factors that may disrupt it. The failure of any phase of the repair process sequence may prevent healing and lead to significant morbidity, resulting in costs.2 The tissue neoformation induction system aims to treat patients who present ulcers from various diseases and do not respond well to conventional treatments, it’s seen as a new form of phototherapy, but with reduced costs due to the use of high brightness LED in place of LASER

The number of people who have chronic wounds in Brazil has increased in recent years. Minimizing the suffering of these people is what motivated the development of anequipment capable of replacing the conventional method of treatment, since it can substantially accelerate scarring processes at a low cost. This equipment is called RAPHA, a mobile tissue neoformation system based on the principles of phototherapy which aims to aid in the healing of wounds, along with a blade made of latex.


The treatment of 4 participants of the research using silver foam and 6 other participants treated using the latex blade associated to the use of LED for 30 minutes were compared. The clinical findings were analyzed qualitatively and quantitatively, demonstrating that the results obtained by the group treated with the LEDs were higher than those obtained by the foam treated group.3 This fact suggests that the tissue neoformation induction system presented here, is characterized by an effective treatment option for diabetic foot ulcer due to the high potential in inducing healing.

After the ulcer closes, remodeling and maturation of the formed scar occurs. This phase takes months or years, and involves reducing the number of cells and blood flow in scar tissue, reformulating and improving the components of collagen, and reabsorption of water. Maturation is responsible for increased tensile strength (maximum 80% of normal skin force) and decreased scar size.4

In this way, it can be seen that wound healing has been studied with several covering techniques to Hevea brasiliens is better treat the wound and demonstrate healing effectiveness. The use of new coatings, among them the use of latex of in animals5–7 and humans.3,8–13


Therefore, the method of treatment of ulcers through LEDs associated with a latex blade is shown as a positively differentiated approach to those already presented in the literature and currently used in research participants with ulcers in the lower limbs. The RAPHA equipment is intended to treat ulcers presented in external regions of the body which may interact with the light provenient from LEDs, such as diabetic ulcers, which is a chronic wound that occurs in people who, for various reasons, have had a complication of diabetes, pressure ulcers which are very common in bedridden or mobility impaired patients as it is caused by too much pressure in a region of the body that ultimately damages the skin.


The research group thanks the federal entities that supported the project: Ministry of Health of Brazil through the Department of the Industrial Complex and Innovation in Health (DECIIS) and the Engineering and Innovation Laboratory (LEI/UnB).

Conflict of interest

The author declares no conflict of interest.


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