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eISSN: 2574-9838

International Physical Medicine & Rehabilitation Journal

Research Article Volume 6 Issue 4

Right VI palsy revealing nasopharyngeal cancer (UCNT)

H Belatik,1,2 H Attifi,1,2 M Hmidi,1,2 N Touihem,1,2 A El boukhari,1,2 K Nadour1,2

1Department of otolaryngology, Moulay Ismail Military Hospital, Meknes, Morocco
2Faculty of medicine and pharmacy, Sidi Mohamed Ben Abdellah University, Fes, Morocco

Correspondence: H Belatik, department of otolaryngology, Moulay Ismail Military Hospital, Meknes, Morocco, 50000, faculty of medicine and pharmacy, Sidi Mohamed Ben Abdellah University, Fes, Morocco 30000, Tel +212 664667962

Received: August 06, 2021 | Published: December 31, 2021

Citation: Belatik H, Attifi H, Hmidi M, et al. Right VI palsy revealing nasopharyngeal cancer (UCNT). Int Phys Med Rehab J. 2021;6(4):99-101. DOI: 10.15406/ipmrj.2021.06.00292

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Abstract

  1. VI paralysis is a frequent and classic pathology in the clinical consultation of ophthalmology. The main difficulty is the diagnostic process (for the etiology).
  2. In young adults, be aware of the possibility of a tumor with the correlation of rapid imaging.
  3. UCNT is frequent in Morocco, its neurological symptoms are misleading because we do not always think of examining the nasopharynx properly in the event of damage to the cranial pairs.
  4. Improving the prognosis for this cancer requires early diagnosis.

Keywords: nasopharynx, VI palsy, MRI

Abbreviations

UCNT, Undifferentiated nasopharyngeal carcinomas; ENT, ear, nose, throat, and neck; MRI, Magnetic resonance imaging;

Introduction

VI palsy is characterized by damage to the lateral rectus muscle, preventing abduction of the paralyzed eye.

The aetiologies vary depending on the Age. In young adults, Any VI paralysis should primarily suggest a tumor cause.

Nasopharyngeal cancer is common in Morocco. Undifferentiated nasopharyngeal carcinomas (UCNT) constitute the predominant histological group.

Due to its deep basal cranial topography not very accessible to examination, and despite a rich but misleading borrowing symptomatology, this cancer remains a late diagnosis and a formidable prognosis.

The objective of our study is to encourage ENT surgeons to think about a UCNT in front of a paralysis of the VI

Materials and methods

This is a 46-year-old patient, with no particular pathological history, who presented for a consultation for an oculomotor disorder in his right eye with horizontal binocular diplopia (more marked in far vision) associated with occipital headaches in progressive installation (during 3 months) all evolving in a context of apyrexia.

Results

The ophthalmological examination

Shows a 10/10 VA (P2) in ERL with normal anterior and posterior segment.

Oculomotor examination:

  1. Compensatory attitude with the head turned to the right.
  2. A constant esotropy of the right eye in the primary position (Figure 1).
  3. A deficit of abduction of the right eye (limitation of the external right ER and hyperaction of the internal right EL in favor of a paralysis of the VI of the right eye) (Figure 2).
  4. Horizontal binocular diplopia (red glass) which worsens in far vision and especially in the right lateral gaze.
  5. The VI palsy of the right eye is confirmed by the Lancaster (Figure 3). 

Figure 1 Esotropia of the right eye in primary position.

Figure 2 Right eye abduction deficit.

Figure 3 Lancaster in favor of VI palsy of the right eye.

The general examination (ENT and neurological) and without particularities.

  1. The ophthalmological examination is completed by a biological and radiological assessment and a neurological and ENT opinion.

Biology: The study of cerebrospinal fluid is normal.

EBV serology: high level of anti-EBV antibodies.

CT of the sinuses: nasal septum deviated to the left with thickening of the lower septa.

Orbito-cerebral MRI: in favor of a right nasopharyngeal neoplastic process, extended to the right cavernous compartment (Figure 4A,4B).

Figure 4A & 4B Orbito-cerebral MRI (coronal and sagittal slice) in favor of a right nasopharyngeal neoplastic process, extended to the right cavernous compartment.

Histology: deep nasopharyngeal biopsy showing undifferentiated nasopharyngeal-type carcinoma (UCNT).

  1. An alternating occlusion associated with analgesic treatment was started to limit the development of contractures and fight against pain.

Discussion

Among oculomotor palsies, VI (peripheral type) is the most common, around 44%. It is often acquired and marked by a high percentage of recovery.1

A positive diagnosis is relatively straightforward, since this nerve invades only the ipsilateral lateral rectus.

The aetiologies vary depending on the age:

  1. In older patients (average 65 +/- 3 years), approximately 20% of VI paralysis is the consequence of microvascular disease.1
  2. In children, Apart from congenital forms, the traumatic aetiology is most frequently found before neoplasias.
  3. In the group of young adults (20-50 years): the tumor cause predominates (33% of cases).

In Morocco (intermediate risk areas), the incidence of nasopharyngeal cancer is high. It occurs at any age and the sex ratio is 3H/F.2

UNCT (the most frequent histological type) is a particular form due to its evolution, its high metastatic potential, its high radiosensitivity and its etiological relationship with EBV.

Cervical symptoms: lymphadenopathy (50 to 90% of cases) represent the most frequent circumstance of discovery, after otological (25%) and rhinological (20%) symptoms.3, 4

Neurological symptoms (such as oculomotor paralysis of VI (diplopia), headaches, etc.) are the rarest (10 to 15% of cases); they are misleading and testify to an invasion of the base of the skull.5

CT and MRI are recognized as complementary imaging techniques for the initial assessment (locoregional extension).6,7

The dosage of anti-EBV antibodies is systematic before starting treatment. Their rate is often high in the case of UCNT. The anti-VCA IgA level is very specific for undifferentiated nasopharyngeal carcinoma.8

UCNT is a very chemo- and radiosensitive or even radiocurable tumor. Irradiation remains the standard treatment for this disease.9

The prognosis is poor, overall 5-year survival being 35%. However, it is a function of the extension at the base of the skull that worsens the prognosis.

Conclusion

  1. VI paralysis is a frequent and classic pathology in the clinical consultation of ophthalmology. The main difficulty is the diagnostic process (for the etiology).
  2. In young adults, be aware of the possibility of a tumor with the correlation of rapid imaging.
  3. UCNT is frequent in Morocco, its neurological symptoms are misleading because we do not always think of examining the nasopharynx properly in the event of damage to the cranial pairs.
  4. Improving the prognosis for this cancer requires early diagnosis.
  5. Early detection and screening are tested in endemic areas (anti-EBV antibody/viral DNA).

Acknowledgments

None.

Conflicts of interest

The author states there are no conflicts of interest.

Funding

None.

References

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©2021 Belatik, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.