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International Journal of
eISSN: 2381-1803

Complementary & Alternative Medicine

Review Article Volume 9 Issue 4

Acupoint Stimulation for Postoperative Ileus Following Gastrointestinal Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ling-shu Wang,1 Guannan Li,2 Xuetong Gu,2 Jing Li,2 Guang Yang3

1Department of Rehabilitation, Heilongjiang University of Chinese Medicine, China
2Graduate student, Heilongjiang University of Chinese Medicine, China
3Gynaecology and Obstetrics, Heilongjiang University of Chinese Medicine, Harbin 150040, China

Correspondence: Ling-shu Wang, Department of Rehabilitation, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China, Tel 086 15845008592

Received: November 11, 2017 | Published: November 20, 2017

Citation: Ling-shu W, Guannan L, Xuetong G, Jing L, Guang Y (2017) Acupoint Stimulation for Postoperative Ileus Following Gastrointestinal Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Int J Complement Alt Med 9(4): 00302. DOI: 10.15406/ijcam.2017.09.00302

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Abstract

Introduction: Postoperative ileus is a common complication of gastrointestinal surgery, which leads to unsatisfactory outcomes with current therapies. In this review, we examined whether acupoint stimulation after gastrointestinal surgery can help hasten postoperative recovery of the digestive system.

Methods: A literature search for relevant studies (published as of April 2017) was conducted across eight biomedical databases. Randomized controlled trials (RCTs) which compared acupoint stimulation with placebo, no treatment, sham acupuncture, or standard care, in adults with postoperative ileus were eligible for inclusion. Trials which compared a combination of acupoint stimulation and standard care with standard care were also included. The Cochrane risk of bias was used to evaluate study quality. Outcomes were summarized using risk ratio (RR) and mean difference (MD) for binary and continuous variables, respectively.

Results: Fourteen RCTs (combined n=1299) that investigated the role of acupoint stimulation in postoperative ileus after cholecystectomy or colorectal cancer (both open and laparoscopic surgery) were identified and included Chinese and English publications. Most of the trials were found to have a high risk of bias. Results of meta-analysis showed that treatment with acupuncture, moxibustion, electroacupuncture, auriculotherapy, and acupoint injection plus standard care was associated with shorter time to passage of first flatus as compared to that with standard care alone. Acupuncture plus standard care was associated with shorter time to first defecation as compared to that with standard care alone.

Conclusions: There is a paucity of high-quality evidence to recommend the use of acupoint stimulation for treatment of postoperative ileus. Randomized trials with adequate sample size, appropriate blinding and rigorous randomization methods should be undertaken to compare acupuncture with both sham and no acupuncture to generate high-quality evidence on this treatment.

Keywords: Acupoint stimulation; Postoperative ileus; Systematic review; Randomized controlled trial

Abbreviations

CENTRAL: Cochrane Central Register of Controlled Trials; CINAHL: Dhina Network Knowledge Infrastructure; TND: Time to Return to Normal Diet; CI: Confidence Intervals; Rrs: Risk Ratios; TFD: Time To First Defecation

Introduction

Postoperative ileus is a type of bowel dysmotility that may occur after surgery. It is a particularly common occurrence after abdominal surgery and is characterized by bloating due to accumulation of fluid and flatus in the bowel, pain, nausea, vomiting, intolerance to solid food, and delayed passage of flatus and formed stool [1]. The incidence of postoperative ileus among patients who underwent colectomy in United States in the year 2004 was 17.4% [2]. The etiopathogenesis of postoperative ileus is not completely understood; however, surgical manipulation, inflammatory response, and inhibitory neural reflexes are believed to be involved in its causation [3-5]. Postoperative ileus accounts for a considerable morbidity and economic burden and has a detrimental effect on patient satisfaction [6-7]. Acupuncture and moxibustion are traditional Chinese medical modalities that have been in use over the past 2000 years. Acupuncture involves piercing of meridian points (acupoints) on the body with needles for therapeutic purposes. Moxibustion involves the application of smoldering moxa cones or sticks directly or indirectly on acupoints. With advances in acupuncture techniques, other methods for therapeutic stimulation of acupoints on the basis of meridian theory have emerged, including auriculotherapy (puncture of certain reactive spots on the auricle), electroacupuncture (EA; a combination of needling and electrostimulation), acupoint injection (AI; injection of certain Chinese and/or Western pharmaceutical agents into acupoints), acupressure (application of pressure over acupoints instead of needles), and catgut embedment at the acupoints (CE; implantation of chromic catgut into acupoints for continuous stimulation).

Both animal experiments and clinical studies have shown that acupuncture can induce gastrointestinal transit after abdominal surgery and normalize gastrointestinal function [8-11]. Moreover, EA has been found to promote colonic motility and prevent formation of postoperative intra-abdominal adhesions [12,13]. Moreover, EA stimulation of acupoints was shown to enhance peristalsis after surgery [14,15], and acupuncture was shown to alleviate intra-abdominal adhesions, accelerate postoperative recovery of mitochondrial and rough endoplasmic reticulum function in the intestinal cells, and to increase the small intestinal transit rate in rats [16-18]. To our knowledge, the currently available evidence pertaining to the effects of acupoint stimulation on postoperative ileus has not been systematically appraised. In this review, we sought to examine whether acupoint stimulation can reduce the duration of postoperative ileus in patients who have undergone open or laparoscopic gastrointestinal surgery.

Methods

Search strategy

A literature search for relevant studies was conducted on the following online biomedical databases: the Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; CINAHL; China Network Knowledge Infrastructure; Wan Fang Database; VIP Database for Chinese Technical Periodicals; and Chinese Biomedical Database. Studies published as of April 2017 were eligible for inclusion. A combination of the following key words were used for the literature search: "ileus", "postoperative", "acupuncture", "moxibustion", "auriculotherapy", "electroacupuncture", "acupoint injection", "acuppressure", and "catgut embedding at acupoints". Titles and abstracts of all retrieved articles were independently screened by two researchers (XTG and GNL) for eligibility. In the second step, full texts of articles were reviewed against the study-selection criteria. Finally, the reference lists of included studies were manually searched to identify any additional studies. No language restriction was employed in the literature search.

Any disagreements on study inclusion between the two reviewers were resolved by participation of a third reviewer (LSW) who made the final decision independently.

Inclusion criteria

  1. Type of studies: Only randomized controlled trials were included.
  2. Types of participants: Adult patients undergoing open or laparoscopic gastrointestinal surgery for ileus or bowel obstruction for the first time, regardless of the setting (emergency or elective surgery). Ileus was considered only if it occurred within 72 hours postoperatively [19].
  3. Types of interventions: Acupoint stimulation in the postoperative period was included, irrespective of frequency, operative duration every time, number of points, and treatment sessions. Methods for acupoint stimulation in the intervention groups included: (1) acupuncture; (2) moxibustion; (3) auriculotherapy; (4) electroacupuncture; (5) acupoint injection; (6) acupressure (7) catgut embedding at acupoints.
  4. Control groups in the selected RCTs received the following, regardless of details of treatment: No treatment (NT); Placebo; Sham acupuncture (SA); standard care (SC). In addition, we included acupoint stimulation plus standard care compared against the same standard of care.

  5. Type of outcome measures: The primary outcome was time to passage of first flatus (TFF; up to 72 hours, calculated as number of hours after the end of surgery to the first observed passage of flatus). The secondary outcomes were:(1) time to first defecation (TFD; up to 72 hours, calculated as number of hours after the end of surgery to the first observed passage of stool); (2) length of hospital stay (LOS; in days); (3) time to return to normal diet (TND; hours; up to 72 hours); (4) mortality (up to 30 days because of ileus); (5) adverse events related to acupoint stimulation (e.g., pain, hematoma, bleeding).

Data extraction

From the selected studies, data were independently extracted by two reviewers (XTG and GNL) using a novel data extraction form developed for this review. Two other reviewers (GY and JL) then checked and entered the data into the Review Manager 5 software.

Data pertaining to the following variables related to acupuncture treatment were extracted: type of acupoint stimulation, treatment frequency, treatment duration, length of each treatment session, and number of points used. Other extracted data elements included author details, title of study, year of publication, study design, disease, sample size, treatment, type of control interventions, TFD, TFF, LOS, and complications related to acupoint stimulation.

Assessment of risk of bias

All studies were independently evaluated for risk of bias by four reviewers (XTG, GNL, JL, and GY). The risk of bias was categorized as low, high, or unclear using the criteria specified in the Cochrane Risk of Bias Tool. Disagreements, if any, among the reviewers were resolved by consensus. Bias with regard to random sequence generation, concealment of allocation, blinding (or masking), incomplete outcome data, selective reporting of outcomes, and other sources of bias were evaluated.

Data analysis

Statistical analyses were conducted using Review Manager 5. Continuous variables are presented as mean differences (MDs) with 95% confidence intervals (CI), and dichotomous data as risk ratios (RRs) with 95% CI. Trials were included in the meta-analysis if they were reasonably homogeneous with regard to study design, participants, interventions, control, and outcome measures.

Results

Description of studies

A total of 2688 articles (CENTRAL, 14; MEDLINE, 16; EMBASE, 121; CINAHL, 4; CNKI, 1477; VIP, 376; WanFang, 389; CBM, 291) were retrieved on initial search; of these, 878 records were retained after elimination of duplicates. After screening of titles and abstracts, 816 trials were excluded. Full-texts of 62 articles were reviewed, of which 48 studies were excluded. Finally, only 14 studies qualified for inclusion in this review (Figure1).

Figure 1: Schematic illustration of literature search and study-selection criteria.

Details of these 14 trials [20-33] are listed in Table 1. Three RCTs incorporated three treatment arms each [24,28,32]. All of the studies had similar design and were conducted after laparoscopic or open surgery for cholecystectomy or colorectal cancer. Twelve articles [20-26,29-33] were published in Chinese language and two [27,28] in English language between 2008 and 2016. All trials were single-center trials.

Reference

Country

Design

No. of Patients
(TG/CG)

Mean Age (Years)
(TG/CG)

Surgery

Type

Open/Laparoscopic

Chen [21]

China

two-arm parallel group randomized trial

40 (24/16)

58/58

colon cancer and rectal cancer surgery

laparoscope surgery

 

Yang [31]

China

two-arm parallel group randomized trial

62 (32/30)

68.59±2.44/69.97±1.59

cholecystectomy

laparoscope surgery

Kou [27]

China

two-arm parallel group randomized trial

40(20/20)

58±21/58±11

gallstone surgery

open surgery

Guo [23]

China

three-arm parallel group randomized trial

50 (25/25)

NR

colorectal cancer

laparoscope surgery

Cai [20]

China

two-arm parallel group randomized trial

78(39/39)

57.3/56.4

cholecystectomy

open surgery

Guo [24]

China

two-arm parallel group randomized trial

90 (30/30/
30)

NR

colorectal cancer

laparoscope surgery

Fu [22]

China

two-arm parallel group randomized trial

60(30/30)

48/47

benign gallbladder polyps, gallstone

laparoscope surgery

Qian [29]

China

two-arm parallel group randomized trial

62(31/31)

NR

colorectal cancer surgery

open surgery

Zhang ML [32]

China

three-arm parallel group randomized trial

136(46/45/45)

63/64/61

gastrointestinal
surgery

open surgery

Jin [25]

China

two-arm parallel group randomized trial

216(108/
108)

42.42±12.58/
43.48±11.38

cholecystectomy

laparoscope surgery

Zhang P
[33]

China

two-arm parallel group randomized trial

60 (30/30)

NR

cholelithiasis

open surgery

Ng [28]

China

three-arm parallel group randomized trial

165(55/55/55)

NR

colorectal cancer

laparoscopic surgery

Sun [30]

China

two-arm parallel group randomized trial

90 (30/30/ 30)

NR

cholecystectomy surgery

laparoscopic surgery

Jin [26]

China

two-arm parallel group randomized trial

150(75/75)

52.0±12.5/51.0±10.4

gallstone surgery

open surgery

Table 1: Characteristics of the included studies.

These 14 trials included a total of 1299 participants. All cases of postoperative ileus were treated in hospital. Gastrointestinal surgery included cholecystectomy and surgery for colorectal cancer. Study sample sizes ranged from 40 to 216 patients; age of patients ranged from 18 to 85 years. Patients were recruited based on clinical presentation of delayed passage of first flatus and defecation, and intolerance to solid food after gastrointestinal surgery. Only one study protocol [28] was reviewed by an institutional review board and reported study participation with informed consent from patients (Table 1).

Acupoint stimulation in treatment groups included acupuncture [27,30], moxibustion [23,24], EA [31,28], auriculotherapy [22,25,33], AI [20,24,32], acupressure [21,32], and CE [29], all of which were accompanied by standard care and compared with the same standard of care in the control group. Only SS Ng et al. [28] compared EA and SA. None of the studies compared acupoint stimulation with placebo or acupoint stimulation with no treatment. There were no reports of mortality or adverse events related to acupoint stimulation in any of the studies included in this review. Detailed information on acupoint stimulation is presented in Table 2.

Reference

No. of Patients
(TG/CG)

Age (Years)
(TG/CG)

Interventions

Outcomes

TG

CG

 

Chen [21]

40 (24/16)

58/58

Acupressure at Zusanli (ST36) and Hegu (LI4) bilaterally for 20 min at 6 h postoperatively and thereafter repeated once every 4–6 h until first flatus

The same routine
postoperative care as the intervention group, excluding acupressure

TFF

Yang [31]

62 (32/30)

68.59±2.44/69.97±1.59

Electroacupuncture at Zusanli (ST36) and Sanyinjiao (SP6) bilaterally 4 h postoperatively for 20 min and thereafter repeated every 4h until first flatus.

The same routine
postoperative care as
the intervention
group, excluding EA

TFF

Kou [27]

40 (20/20)

58±21/
58±11

Acupuncture with filiform needles (0.3 mm diameter, 40 mm length) on alternate days bilaterally at Zusanli (ST 36), Shangjuxu (ST 37), Xiajuxu (ST 39), and Yanglingquan (GB 34). On detection of needling sensation, the doctor performed 20 s of reinforcing–reducing technique, followed by needling manipulation every 5–10 min with retention for 20–30 min

The same routine
postoperative care as
the intervention
group, excluding Acupuncture

TFF,TFD

Guo [23]

50 (25/25)

NR

Moxibustion, circling moxibustion 2 minutes, then bird-pecking moxibusion 1 minute, and along the facial nerves go and back 2 minutes until the feeling disappear

The same routine
postoperative care as
the intervention
group, excluding moxibustion

TFF

Cai [20]

78 (39/39)

57.3/56.4

Acupoint injection with neostigmine methylsulfate 1 mL into Zusanli (ST36) and Shangjuxu (ST37) at 6 h postoperatively

The same routine
postoperative care as
the intervention
group, excluding AI

 

TFF

Guo [24]

90 (30/30/30)

NR

Group 1 received moxibustion at Zhongwan (CV12), Tianshu (ST25), Shangjuxu (ST37), and Zusanli (ST36), first at 6 h postoperatively and thereafter once daily until recovery of bowel movement (>3 bowel sounds per minute on auscultation). Group 2 received acupoint injection of Vitamin B1 100 mg bilaterally into Zusanli bilaterally, first 6 h postoperatively and thereafter once daily until recovery of bowel movement.

The same routine
postoperative care as
the intervention
group, excluding acupoint
Injection and moxibustion

TFF

Fu [22]

60 (30/30)

48/47

Auriculotherapy using Semen Vaccariae administered at CO4, CO7, CO6, and CO17 at 4 h postoperatively and pressed for 5 min until heat sensation was elicited and thereafter repeated every 2 hours until the first flatus

The same routine
postoperative care as
the intervention
group, excluding acupoint
Injection and moxibustion

TFF

Qian [29]

62 (31/31)

NR

Catgut 1.5 cm implanted into Zusanli (ST36) for continuous stimulation at 6 h postoperatively

The same routine
postoperative care as
the intervention
group, excluding CE

 

TFD, TFF, LOS, TND

Zhang ML
[32]

136 (46/45/45)

63/64/61

Group 1 Acupoint injection with neostigmine methylsulfate 0.5 mL into Zusanli (ST36), every 12 hours at a time; Group 2 acupressure at Zusanli (ST36) for 10~15min each time and thereafter repeated once every 4 hours.

The same routine
postoperative care as
the intervention
group, excluding acupoint
Injection and
Acupressure

TFF

Jin [26]

216 (108/108)

42.42±
12.58/43.48±11.38

Auricular acupuncture using Semen Vaccariae administered at CO7, CO6, AT4, AT6a, and TF4 at 6 h postoperatively and pressed 30-60 s until heat sensation was elicited; thereafter repeated every 2 hours until the first flatus

The same routine
postoperative care as
the intervention
group, excluding auriculotherapy

TFF ,
TND

Zhang P
[33]

60 (30/30)

NR

Auriculotherapy with Semen Vaccariae fixed on to auricular acupoints of CO4, CO7, CO6, CO17, CO18, and AH6a with each acupoint pressed for 0.5 min at 6 h postoperatively, then repeated every 10 min at the seventh hour, and thereafter repeated once every hour until first flatus

The same routine
postoperative care as
the intervention
group, excluding auriculotherapy

TFD, TFF

Ng [28]

165 (55/55/55)

NR

Electroacpuncture applied bilaterally at Zusanli (ST36), Sanyinjiao (SP6), Hegu (LI4), and Zhigou (TE6), at 100 Hz for 20 min, with depth of insertion ~20 mm. EA group underwent treatment from POD 1, repeated for 3 days or until TFF.

The same routine
postoperative care as
the intervention
group, excluding EA.
Shorter needles were inserted into shallower areas away from acupoints in the SA group. SA group underwent treatment from POD 1, repeated for 3 days or until TFF.

TFD,
TND,LOS

Sun [30]

90 (30/30/30)

NR

Acupuncture with filiform needles applied bilaterally at Zusanli (ST36), Daimai (GB26) for 30 min, then repeated after 6 h on POD 1

The same routine
postoperative care as
the intervention
group, excluding
acupuncture

TFD,TFF

 

 

 

 

 

 

Jin [26]

150 (75/75)

52.0±12.5/
51.0±10.4

Acupuncture with filiform needles applied bilaterally at Zusanli (ST36), Yanglingquan (GB35), Shangjuxu (ST37) for 25~30 min, once daily

The same routine
postoperative care as
the intervention
group, excluding
acupuncture

TFD,TFF

Table 2: Detailed information on acupoint stimulation.

TFD: Time To Passage of First Flatus; TFFL: Time to First Defecation; LOS: Length Of Hospital Stay; TND: Time To Return To Normal Diet; TG: Treatment Group; CG: Control Group; NR: Not Reported;SC: Standard Care; EA: Electroacupuncture; SA: Sham Acpuncture; AI: Acupoint Injection; CE: Catgut Embedding At Acupoints

Methodological quality

The 14 studies included in the review were of poor methodological quality (Figure 2). Three studies [25, 26,33] reported using a random number table or coin toss, and were accordingly judged as having a low risk of bias. No information on randomization of subjects was specified for the other 11 studies; these were deemed to have a potentially high risk of bias. Only SS Ng et al. [28] reported the use of sealed envelopes for treatment allocation and was judged as having a low risk of bias. However, no information on allocation concealment was reported for the remaining 13 trials; these were judged as having an unclear risk of detection bias. Blinding is not possible for acupoint stimulation, especially in China, as most individuals are familiar with acupuncture. However, study by SS Ng et al. [28] had low risk of performance bias as patients were randomized to EA or SA groups and were blinded to the treatment allocation. Qian [29] & Ng [28] reported blinding of statisticians during statistical analyses; these studies were judged as having a low risk of analysis bias. For the remaining 12 studies, no information related to blinding of participants or personnel was reported; accordingly, these were categorized as having an ‘unclear’ risk of performance bias. There were no missing outcome data in the 14 studies included in the review, and thereby, there is a low risk of attrition bias. As protocols for 13 studies were not available, the risk of reporting bias was categorized as ‘unclear’. Only 1 article reported sample size calculation and was judged to be at a low risk of bias.

Figure 2: Summary of the risk of bias.

Effects of interventions

Primary outcome

  1. Time to passage of first flatus: All trials reported data on time to passage of first flatus. Results of meta-analysis showed that treatment with acupuncture (MD: -17.33h, 95% CI, -19.40 to -15.26; 3 trials, I2=0%, REM), moxibustion (MD: -10.35 h, 95% CI, -12.12 to -8.58; 2 trials, I2=0%, REM), auriculotherapy (MD: -12.80 h, 95% CI, -21.09 to -4.5; 3 trials, I2=97%, REM), EA (MD: -16.02 h, 95% CI, -21.55 to -10.49; 2 trials, I2=0%, REM) and AI (MD: -10.60 h, 95% CI, -16.13 to -5.07; 3 trials, I2=88%, REM) plus SC was associated with shorter TFF as compared to that with SC alone. CE plus SC was associated with shorter TFF as compared to that with SC alone. However, no significant difference in TFF was observed between EA versus SA, and acupressure plus SC versus SC arms. The forest plot is presented in Figure 3.

Figure 3: Forest plot of time to passage of first flatus.

SC: standard Care; EA: Electroacupuncture; SA: Sham acpuncture; AI: Acupoint injection; CE: Catgut Embedding at Acupoints

Secondary outcomes

  1.  Time to first defecation: Five trials reported data pertaining to time to first defecation (TFD). Results of meta-analysis showed that treatment withacupuncture (MD: -10.16 h, 95% CI -19.01 to -1.32, 3 trials, I2=77%, REM) plus SC was associated with shorter TFR as compared to that with SC alone. Auriculotherapy plus SC and CE plus SC were associated with shorter TFD as compared to that with SC alone (Table 3).
  2. Interventions and Outcomes

    Study ID

    Sample Size (I/C)

    Effect Estimates (95% CI)

    Time to First Defecation

     

     

     

    Acupuncture+SC vs. SC

    Jin [26]

    150 (75/75)

    MD: -10.16 [-19.01,-1.32]

    Kou [27]

    40 (20/20)

     

    Sun [30]

    60 (30/30)

    I²=77%, REM

    Auriculotherapy+SC vs. SC

    Zhang P [33]

    60 (30/30)

    MD: -24.48 [-30.52,-18.44]

    CE+SC vs. SC

    Qian [29]

    62 (31/31)

    MD: -12.86 [-21.34,-4.38]

    Length of Hospital Stay

     

     

     

    EA+SC vs. SC

    Ng [28]

    110(55/55)

    MD: -2.00 [-3.40,-0.60]

    EA vs. SA

    Ng [28]

    110 (55/55)

    MD: -0.30 [-1.03,0.43]

    CE+SC vs. SC

    Qian [29]

    62 (31/31)

    MD: -2.43 [-5.24,0.38]

    Time to Return to Normal Diet

     

     

     

    EA+SC vs. SC

    Ng [28]

    110 (55/55)

    MD: -19.20 [-33.68,-4.72]

    EA vs. SA

    Ng [28]

    110 (55/55)

    MD: -2.40 [-11.03,6.23]

    Auriculotherapy+SC vs. SC

    Jin [25]

    216 (108/108)

    MD: -6.48 [-6.79,-6.17]

    CE+SC vs SC

    Qian [29]

    62 (31/31)

    MD: -13.44 [-36.54,9.66]

    Table 3: Effect estimates of the secondary outcomes for postoperative ileus.

    REM: Random Effects Model; MD: Mean Difference; SC: Standard Care; EA: Electroacupuncture; SA: Sham Acupuncture; CE: Catgut Embedding At Acupoints; I/C: Intervention/Control

  3.  Length of hospital stay: Data pertaining to LOS were available only for two trials. Treatment with EA plus SC was associated with shorter LOS as compared to that with SC alone. However, no significant difference was observed in this respect between EA and SA or between CE plus SC and SC groups (Table 3).
  4.  Time to return to normal diet: Data pertaining to time to return to normal diet (TND) was available only for three trials. No significant difference was observed with respect to TND between CE plus SC and SC groups or between EA and SA groups. However, treatment with auriculotherapy plus SC and EA plus SC was associated with significantly shorter TND as compared to that with SC alone (Table 3).
  5.  Mortality: None of the trials reported data on mortality.
  6.  Adverse events: None of the trials reported data on adverse events.

Discussion

Main findings

A total of 14 studies with a combined study population of 1299 patients were included in this review. The selected studies investigated the role of acupoint stimulation in patients who developed postoperative ileus after cholecystectomy or surgery for colorectal cancer (both laparoscopic and open surgery). In most of the studies, acupoint stimulation was associated with significant shortening of TFD and TFF as compared to that associated with standard care.

Limitation

Firstly, the included studies showed significant clinical heterogeneity with respect to age and sex of patients, preoperative preparation, surgical anesthesia, postoperative analgesia, intraoperative bleeding, routine postoperative care, background of acupuncturists, and precise description of the control group. Secondly, protocols for acupoint stimulation were not defined with respect to time of initiation, number, and depth of needle insertion, number of treatment sessions, frequency and duration of treatment sessions, and details of other interventions administered to the acupoint group. Moreover, adverse events were not reported from any of the studies. Therefore, the safety aspects of this treatment in patients with postoperative ileus could not be determined. Thirdly, in most studies, data on TFF was based on patient self-reporting, the reliability of which is open to question.

Comparison with other Reviews

Wang et al. [35] reviewed the use of acupoint injection with different medicines for prevention of postoperative ileus. In their meta-analysis, acupoint injection of neostigmine, vitamin B1, or metoclopramide compared to usual care showed a beneficial effect on the time to recovery of bowel sounds, TFD or TFF. The outcome was similar to that used in the present study. However, due to poor methodological quality, definitive conclusions could not be derived [34].

Conclusion

The evidences included in this review have a lot of unclear risk of bias because of lack of sufficient information. Moreover, none of the studies provided information on adverse events related to acupoint stimulation. Therefore, this treatment for patients with postoperative ileus needs to be further studied in terms of efficacy and safety.

High-quality randomized controlled trials of acupoint stimulation for treatment of postoperative ileus are required. These should employ adequate sample size, rigorous randomization methods and appropriate blinding techniques. Moreover, in this modality of treatment, blinding of assessors and statisticians would be more realistically feasible.

Funding Source

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Authors Contribution

LSW: protocol development, literature search, quality assessment of trials, development of final review.
XTG: literature search, assessment of trials, data extraction, data entry.
GN L: development of final review.
JL: literature search, assessment of trials, data extraction.
GY: data input.

Conflict of Interest

All authors declare that they have no conflict of interests.

Acknowledgements

Special thanks to Yi Li from Heilongjiang University of Chinese Medicine for his advice on the inclusion criteria.

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